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aucell score  (BioTuring Inc)
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BioTuring Inc aucell score
(A) t-SNE with Louvain clustering of DRG neurons from reanalyzed single nuclei RNA sequencing . (B) Expression density of select genes on the t-SNE plot. (C) Average expression level and frequency of selected marker genes of established neuronal subsets within each cluster. (D) Average expression level and frequency of genes selected during marker. Analysis of putative pruriceptors clusters C6, C9, and C11 from BioTuring “ find markers ” function. (E) Average expression level and frequency of select genes involved in type 2 cytokine receptor signaling within each cluster. (F) t-SNE plots depicting the expression density of type 2 <t>cytokine</t> <t>receptors</t> IL-4Rα and IL-13Rα1. (G) Enrichment scores of type 2 cytokine-associated signaling genes highlighted in blue in panel (E) . <t>AUCell</t> score for each neuron is represented in the indicated color scale for each cell in the scatter plot (top) and as an average for each cluster (bottom). DRG, dorsal root ganglion; IL, interleukin; t-SNE, t-distributed stochastic neighbor embedding.
Aucell Score, supplied by BioTuring Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) t-SNE with Louvain clustering of DRG neurons from reanalyzed single nuclei RNA sequencing . (B) Expression density of select genes on the t-SNE plot. (C) Average expression level and frequency of selected marker genes of established neuronal subsets within each cluster. (D) Average expression level and frequency of genes selected during marker. Analysis of putative pruriceptors clusters C6, C9, and C11 from BioTuring “ find markers ” function. (E) Average expression level and frequency of select genes involved in type 2 cytokine receptor signaling within each cluster. (F) t-SNE plots depicting the expression density of type 2 cytokine receptors IL-4Rα and IL-13Rα1. (G) Enrichment scores of type 2 cytokine-associated signaling genes highlighted in blue in panel (E) . AUCell score for each neuron is represented in the indicated color scale for each cell in the scatter plot (top) and as an average for each cluster (bottom). DRG, dorsal root ganglion; IL, interleukin; t-SNE, t-distributed stochastic neighbor embedding.

Journal: Frontiers in Molecular Neuroscience

Article Title: Type 2 cytokines sensitize human sensory neurons to itch-associated stimuli

doi: 10.3389/fnmol.2023.1258823

Figure Lengend Snippet: (A) t-SNE with Louvain clustering of DRG neurons from reanalyzed single nuclei RNA sequencing . (B) Expression density of select genes on the t-SNE plot. (C) Average expression level and frequency of selected marker genes of established neuronal subsets within each cluster. (D) Average expression level and frequency of genes selected during marker. Analysis of putative pruriceptors clusters C6, C9, and C11 from BioTuring “ find markers ” function. (E) Average expression level and frequency of select genes involved in type 2 cytokine receptor signaling within each cluster. (F) t-SNE plots depicting the expression density of type 2 cytokine receptors IL-4Rα and IL-13Rα1. (G) Enrichment scores of type 2 cytokine-associated signaling genes highlighted in blue in panel (E) . AUCell score for each neuron is represented in the indicated color scale for each cell in the scatter plot (top) and as an average for each cluster (bottom). DRG, dorsal root ganglion; IL, interleukin; t-SNE, t-distributed stochastic neighbor embedding.

Article Snippet: Therefore, we performed an additional analysis looking at the composite enrichment of receptors and signaling components associated with IL-4, IL-13, and IL-33 using the AUCell score ( ) implemented in BioTuring’s Talk2Data browser (genes used are highlighted in blue in ).

Techniques: RNA Sequencing, Expressing, Marker